Wales coach Wayne Pivac has named Gloucester wing Louis Rees-Zammit and Saracens centre Nick Tompkins among five uncapped players in his maiden Six Nations squad, while there is a return for Toulon scrum-half Rhys Webb.
Webb, who missed the 2019 Rugby World Cup due to playing in France, is eligible for selection again after it was confirmed he will return to Wales with the Ospreys next season.
Rees-Zammit, 19, has exploded onto the scene with Gloucester in the Premiership and Champions Cup this season, scoring nine tries in 10 games.
Tompkins has played for England at U18, U20 and Saxons level, but the 24-year-old qualifies for Wales due to ancestry from Wrexham.
Elsewhere, Sale prop WillGriff John, Wasps’ Will Rowlands and Scarlets back Johnny McNicholl are the other uncapped players named by Pivac in the 38-man squad.
No 8 Taulupe Faletau, who has not played for Wales since March 2018, is also included in the squad, which lock Alun Wyn Jones skippers.
Wales begin their 2020 Six Nations campaign at home to Italy on Saturday February 1 (2.15pm) before travelling to face Ireland in Dublin a week later (also 2.15pm).